When and where
Gareth Taylor's side travel to Prenton Park on Wednesday 4 November in a 14:00 (UK) kick-off.
The game will be shown live in the UK via the FA Player.
You can also follow the action via our dedicated matchday Twitter account: @ManCityWomen.
For safety reasons in the wake of the pandemic, the fixture will be played behind-closed-doors.
In line with current protocols, additional balls will be placed at intervals around the pitch.
Should the game remain level after 90 minutes, both teams will receive a point, while the winner shall be determined by a penalty shoot-out, earning a bonus point.
Gareth Taylor could ring the changes a matter of days after Sunday's Women's FA Cup triumph over Everton.
The City boss has no new injury concerns with everyone seemingly returning from Wembley unscathed.
Manager's preview: Gareth Taylor
“The Women's FA Cup Final win gives us a platform to push on. I expect us to compete. City have a reputation: we fight to the end, and we’ll fight in all competitions.
“We’ll draw on the resources of the squad. We understand everyone else wants to be successful. To get a trophy under our belts in the second month of the season is great.
“The players have been first-class and the staff have been great. I am new, I am going to make mistakes but I will try and do everything I can to bring success to this Club.”
Last time out
City won the Women’s FA Cup for the third time in four years on Sunday, successfully defending the trophy with a 3-1 victory over Everton at Wembley in the 50th edition of the tournament.
Substitutes Georgia Stanway and Janine Beckie struck in extra-time to snatch the win, as the holders produced a spirited display to edge the Toffees in a tense encounter at Wembley, after the two sides had played out an enthralling 1-1 in normal time with Valérie Gauvin cancelling out Sam Mewis' opener.
Having lifted the trophy in May 2019, City had held the honour for a total of 547 days heading into this clash and triumphant in the first of two FA Cup tournaments this season, ensured our name will remain on the prestigious silverware for at least another six months…
Gemma Bonner scored against her former club to give City a hard-fought 1-0 win over a stubborn Reds side at the Academy Stadium back in December.
The defender nodded home Caroline Weir’s pinpoint free-kick midway through the first half to stretch Nick Cushing’s side's winning run to five games in all competitions, though City created enough chances to secure a more comfortable victory.
Liverpool were indebted to keeper Anka Preuss, who made a couple of fine saves and forced Ellie Roebuck to do the same as they rallied during the closing stages.