Having already beaten cross-town rivals United this season in the Premier League, City will go into the game with confidence despite a tough run of results.
City's prolific Nigerian striker on EFL Cup derby day...
The Spanish side have returned part of their ticket allocation, which means more Blues can cheer on Pep Guardiola’s men from South Stand Level 1for this crucial European fixture.
The Argentine produced an impressive reflex save to keep out Nolito's thunderous volley as the squad enjoyed a spot of shooting practice at the CFA.
Ilkay Gundogan previews City's EFL clash with Manchester United
The potential for rotation for the EFL Cup fourth round tie sparked debate about possible team line-ups, while there was plenty of pick-up on boss Pep Guardiola's backing for star striker Sergio Aguero.
That was exactly what happened this weekend when Fernandinho replied to a fan in Brazil and invited him to be his mascot during the game against Southampton.
Yaya Toure, Samir Nasri and Carlos Tevez and Dennis Tueart star in our round-up of League Cup classics.