City face the Reds on Sunday 26 January, as Nick Cushing's side begin our defence of the trophy with our third professional women's Manchester Derby clash.
Having met in the league and Continental Cup already this season, both sides have registered a win apiece, with City edging the first competitive meeting with a Caroline Weir wonderstrike.
City are the reigning Champions, having clinched our second FA Cup success with a 3-0 triumph over West Ham at Wembley in May.
This is the 50th year of the FA Women's Cup.
Ticket details will be released in due course.
West Ham v Arsenal
Manchester United v Manchester City
Lewes v Billericay Town or Actonians
Charlton Athletic v Chelsea
Everton v London Bees
Burnley v Leicester City
Sheffield United v Birmingham City
London City Lionesses v Reading
Bristol City v Durham
Tottenham v Barnsley
Huddersfield v Ipswich Town
Southampton FC Women v Coventry United
Southampton Women FC v Crystal Palace
Fylde or Sunderland v Watford
Liverpool v Blackburn Rovers
Aston Villa v Brighton & Hove Albion