City have already qualified for the last-16 as group winners having taken 13 points from a possible 15 so far, giving Guardiola additional licence to rotate his side with the Manchester Derby on the horizon.
And ahead of Matchday 6, Pep Guardiola has revealed he has a fully fit squad to choose from, with Aguero maybe ready to be included among the substitutes after training without suffering a reaction to his recent knee issues.
“Everyone is fit. Tomorrow we will decide [on the team],” Guardiola said.
“We will decide tomorrow [whether Aguero is involved]. Maybe he will be on the bench.
“Tomorrow we will see his reaction to his body, not just his knee.
"But the important thing is in the last three, four days he was part of the group and the niggles he had in the recent past disappeared.
“He will be back [playing regularly] when he can train regularly over weeks and weeks and has minutes, minutes, minutes.
"We know Sergio well. He is working incredibly hard to come back. That is the most important thing.
“He needs a little time but we must be patient. We want him back but if the knee responds well he will be back, for sure.
"His quality no-one doubts.
“Everyone has played a lot of minutes, so like I said before we will play to win. I put the best I can put out for a specific game. There isn’t one team for one competition. Everyone is involved and can be part of the team.
“If someone makes a lot of mins or played a lot, then it would be a risk. But what I saw today, everyone is fit.”
Meanwhile, Guardiola has spoken of his respect for Marseille.
City beat the French side 3-0 away from home on Matchday 2, but they showed flashes of real quality, particularly early in the second half.
Going into the final Group C match, they are involved in a straight battle with Olympiakos to see who qualifies for the Europa League and who exits European competition altogether.
Their manager, Andre Villas-Boas, is a coach Guardiola admires – and the City boss says his side will be taking nothing for granted at the Etihad.
"Lot of respect [for AVB]," he said. "He has been at a lot of clubs and had incredible success at Porto - then in England and Marseille. The quality is there.
"Unfortunately he could not get the results in the Champions League. To start with zero points from two games is difficult but the quality is there with [Dimitri] Payet and [Florian] Thauvin.
"The French league is tough. It will be an interesting game.
"Important for them to try and qualify for Europa League but for us too in terms of prestige and confidence."
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