Pep Guardiola's men welcome the Saints to the Etihad Stadium on Saturday 8 October, with kick-off scheduled for 15:00 (UK).
City come into the tie brimming with confidence, having grabbed 11 goals in each of our last two home matches.
We remain unbeaten in the Premier League this season and will go top for at least 24 hours should we avoid defeat against Ralph Hasenhuttl's side.
However, Southampton held City to a goalless draw in their most recent visit to the Etihad Stadium, and will be desperate to pick up their first points since August when they travel north.
Guardiola's men will take nothing for granted ahead of Saturday's showdown, and with a Champions League trip to Copenhagen also on the horizon, FPL managers have been left with some potentially difficult selection dilemmas.
Thankfully, the Scout is on hand once again to provide their expert insight ahead of Saturday's 13:30 deadline.
Phil Foden (£8.1m) can deliver another big return at home to Southampton in Gameweek 10 of Fantasy Premier League.
The midfielder was rested for Manchester City’s midweek win over Copenhagen in the UEFA Champions League.
That suggests he will be fully refreshed to host Saints, who are the only side yet to keep a clean sheet this season.
Foden’s hat-trick at home to Manchester United last weekend earned the England star his career-high 19 points in Fantasy, extending his recent run of returns.
He has blanked just once in his previous five appearances, producing four goals, two assists and 37 points.
James Ward-Prowse (£6.4m) is the visitors’ dangerman, having scored in two of his last three visits to the Etihad Stadium.
Elsewhere, Jarrod Bowen (£8.1m) and Raheem Sterling (£10.0m) can be major differentials in Gameweek 10, with both owned by no more than 9% of managers.
West Ham United’s Bowen hosts Fulham on the back of a goal, assist and 14-point haul in his previous home match.
Chelsea’s Sterling, meanwhile, has amassed 22 points in his three appearances at Stamford Bridge ahead of a visit from Wolverhampton Wanderers.