Pep Guardiola's men welcome Manchester United to the Etihad Stadium on Sunday 2 October, with kick-off scheduled for 14:00 (UK).
It promises to be a thrilling encounter, as two of the Premier League's most in-form teams prepare to do battle.
City remain unbeaten in all competitions this season and would go top of the tree with a victory should Arsenal fail to get the better of north London rivals Tottenham in Saturday's lunchtime kick-off.
However, Erik ten Hag's side have recovered from a slow start to win each of their last four Premier League matches.
It leaves FPL managers with plenty of tricky selection decisions to wrestle with ahead of Saturday's 11:00 deadline.
Thankfully, the Scout is on hand as always to provide some essential information ahead of the latest round of fixtures...
Erling Haaland (£12.1m) looks set to be a decisive figure in the first Manchester derby of 2022/23 Fantasy Premier League.
City's Norwegian is the top-scoring player in Fantasy in his debut campaign, scoring 11 goals and supplying an assist to collect 73 points.
He has proven particularly prolific at the Etihad Stadium recently, scoring a hat-trick and earning 17 points in each of his last two home outings.
The underlying numbers show why Haaland is thriving as the focal point of Pep Guardiola’s attack.
His total of 14 big chances is not only a league-leading figure, it is 11 more than any other City player in the first eight Gameweeks.
Opponent to watch
Marcus Rashford (£6.6m), meanwhile, is the form player for Manchester United, with three goals and two assists in his previous four fixtures.
Fantasy managers on the lookout for a differential pick should consider James Maddison (£7.9m) and Luis Sinisterra (£6.5m), who can both be found in under 8% of squads.
Leicester City’s Maddison hosts a Nottingham Forest side who have conceded 12 goals in their last three matches.
Sinisterra has scored in each of his last two starts ahead of Leeds United’s home encounter with Aston Villa.