When and where
The last eight takes place at Estádio José Alvalade in Lisbon and will kick-off at 20:00 (UK) on Saturday 15 August.
In the UK, the game will be broadcast live on BT Sport 1 and audio commentary will be provided by BBC Radio Manchester.
You can also follow all the action in our Matchday Centre here on mancity.com and on Twitter: @ManCity, whilst our live matchday show, We’re Not Really Here, will begin one hour before kick-off for a City-centric look at the game.
Fans living outside of the UK should check out our global TV listings to find out how they can tune in wherever they are in the world.
From the quarter-finals, all matches will be played as one-off ties at two stadiums in Lisbon, Portugal.
Teams will be able to make five substitutions but will only be allowed to make these changes at three points in the game. These three occasions do not include changes at half-time, between the end of normal playing time and extra time, and at half-time during extra time. One additional substitution will be allowed during extra time.
There will also be more players to choose from: a total of 23 players will be allowed on the match sheet instead of 18, something usually only permitted for the Final.
City: Sergio Aguero is not available, as he continues his recovery from his knee injury.
Benjamin Mendy is available again, having been suspended for the triumph over Real Madrid, while Rodrigo is also in contention, despite suffering from cramp late on in the last 16 clash against the La Liga Champions.
Lyon: Rudi Garcia says he hopes to have a fully-fit squad, although former Blue Jason Denayer and Maxwel Cornet may require face late fitness tests. Kenny Tete (calf) has trained with the squad, while Moussa Dembele could also return.
Pep Guardiola preview
“I think it’s an important moment in our careers. I would prefer to be at home, but this is a special situation. It is comfortable, it is nice to be here. Hopefully we can do a good game and stay a few more days in this lovely country.
“After lockdown they have been incredibly focused. We accepted the deal to help our club go to the semi-final. The format is what it is. We adapted to the new protocol.
“Now we prepare for Lyon. Now is the time to be ourselves. I want to see my team be who they are, do everything with their soul and their minds and after that the football will dictate whether we deserve it or not.”
Rudi Garcia preview
“Having eliminated Juventus and gives us more confidence. An appetite is learned with eating.
“We want to stay for a long time in Lisbon but we know that City is the big favorite in this match. The start of the quarter-finals has showed that surprises can happen.
“We hope that will be the case again on Saturday. I hope we will be as good as the last two games. "
Referee: Danny Makkelie (NED)
Assistant referees: Mario Diks (NED), Hessel Steegstra (NED)
Fourth official: Tasos Sidiropoulos (GRE)
Video Assistant Referee: Jochem Kamphuis (NED)
Assistant Video Assistant Referee: Kevin Blom (NED)
The pair have only met twice competitively, in the 2018/19 Champions League group stage.
The French outfit were victorious at the Etihad Stadium, winning 2-1, before the two sides played out a 2-2 draw in the penultimate group game.
City: We have won ten of our 13 games in all competitions since football returned in June and were in fine form in front of goal, scoring 38 times and conceding just six.
Lyon: Since the conclusion of the Ligue 1 season in March, Lyon played six friendlies in preparation for the French League Cup Final and European last 16 clash against Juventus. They defeated the Italian giants on away goals.
We're Not Really Here
Richard Dunne will make his first appearance as a guest on the We’re Not Really Here matchday show and will be joined by another much-loved past player in the form of Shaun Wright-Phillips for the quarter-final tie.
Cel Spellman and Kyle Walker are the hosts and the live pre-match show begins at 19:00 (UK), one hour before the game kicks-off in Lisbon and you can tune in via all of our digital platforms.
With Dunne and Wright-Phillips offering both their insight into the game’s talking points and recalling their own time at the Club, We’re Not Really Here is the show to watch for a City-centric build-up to the match.
They return at half-time for a summary of the opening 45 minutes and then, five minutes after full-time, our 30-minute post-match show begins when our guests will analyse the action and respond to fans’ questions and polls.
Time permitting, we will also hear a player’s reaction and from Guardiola’s post-match press conference.
For those who can’t watch the action live, a full match replay will be available on CITY+ from midnight (UK) after the game.