We host the Foxes on Sunday 26 December, with kick-off scheduled for 15:00 (UK).
It represents City's final home game of 2021, as Pep Guardiola's men aim to extend our English record of 34 top flight victories across the calendar year.
However, claiming all three points is far from a foregone conclusion against a Leicester side looking to build on a 4-0 victory in their last Premier League match against Newcastle.
FPL managers have some tough selection dilemmas to solve ahead of Boxing Day's 11:30 deadline.
Thankfully, the Scout is on hand, as part of our weekly series, to advise you on one member of Pep Guardiola's men, a Leicester player and one other Premier League star who could pick up the points.
Check out the latest FPL Scout Report, and information on the upcoming Man City FPL Cup, below...
Riyad Mahrez (£8.6m) offers an in-form differential for Gameweek 19 of Fantasy Premier League.
The Manchester City winger welcomes Leicester City on the back of his two season-best scores.
He produced a goal and an assist against both Leeds United and Newcastle United in his previous two outings, claiming 12 and 13 points respectively.
When selected this season, Mahrez has been involved in 40% of Manchester City’s goals, more than any team-mate.
Yet he can be found in just 3% of squads in Fantasy.
The underlying numbers from the last two Gameweeks showcase Mahrez’s all-round influence.
The Algerian’s five shots in the box was a team-leading total and his four shots on target were joint-top with Kevin De Bruyne (£11.9m).
Meanwhile, his seven chances created ranked second only to the Belgian’s nine.
Opponent to watch
James Maddison (£6.8m) is the visitors’ form player, with five goals and six assists in his last seven matches in all competitions.
Familiar foe: Maddison grabbed one goal and one assist in a 21-minute cameo when we last faced Leicester at the Etihad Stadium.
Other Premier League Pick
Elsewhere, Manchester United’s Cristiano Ronaldo (£12.5m) and Tottenham's Son Heung-min (£10.3m) are among the best captaincy picks for Gameweek 19.
Ronaldo faces a Newcastle side who have conceded at least three goals in three successive matches.
Son has produced double-figure returns in three of his last four home meetings with Crystal Palace.
Manchester City Fan League Cup
City's Premier League match against Leicester this weekend kickstarts the Manchester City FPL Cup.
A new feature this season, members of the Man City Club league will go head-to-head in a weekly knockout competition.
There is also an option to introduce this feature to your own created mini-leagues by going to the settings of the league and checking the cup option is ticked!
When the cup begins is determined by the number of managers in the league. Some may get a bye in the first round depending on their previous Gameweek performance.