Fourth-tier Ipswich are the lowest-ranked side left in the competition, while City are top of the WSL and current holders of the cup.
Here’s what they are saying…
Nick Ames writes: ‘The town itself, previously asleep to its women’s team, is waking up, too. Around 400 supporters will travel to Manchester and crowds for home games are the highest in the fourth tier, with 761 attending the derby against Norwich. Something has stirred here although promotion, no certainty in an attritional division, is required soon to ensure Ipswich stay on schedule. The sense around the club is that hauling themselves up a division at last could be the hardest part of a journey to the WSL.
‘Their job at City might top that. Grey, who sees Georgia Stanway as an inspiration but would love to swap shirts with Steph Houghton, believes “anything is possible”. It is an attitude Sheehan, a glint in his eyes as he considers the prospect, detects throughout his ranks.
‘“It’s a monumental task but there’s something about this group,” he says. “They’re so brave, and have so much belief and confidence in each other, that they won’t be fazed. They’ll be licking their lips to get out there and have a go. It’s going to be an incredible weekend.”’
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Richard Cooke writes: 'Paige Peake, 17, is one of the students in the team but she appears undaunted at the prospect of playing against such illustrious opponents.
'"I'm absolutely buzzing for it," she told Sky Sports News. "It will be unbelievable to play against the likes of Steph Houghton and Ellen White if they play, to play against people where I have aspirations of getting to, they've gone to World Cups, they've played at Wembley."
'Captain Amanda Crump, who has been at the club for 14 years, added: "I'm very excited. It's an absolute honour to play for Ipswich Town against such a huge team, against some of the Lionesses, it will be great challenge for us."'