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The game will be played at the Etihad Stadium on Saturday 20 April at 12:30pm BST.
The match is to be shown live on Sky Sports in the UK - you can also keep up-to-date with all the action via our Matchday Centre or our Twitter feed: @ManCity.
You can find out how to watch the game, wherever you are, via our global TV listings.
City: Pep Guardiola says he will assess the fitness of his squad at Friday afternoon's training session. Oleksandr Zinchenko could be back in contention for selection after having returned to training on Thursday...
Spurs: Moussa Sissoko is an injury doubt, having been substituted on Wednesday because of a groin problem. Eric Dier will return to training on Friday after a hip injury and could be involved this weekend. Serge Aurier, Harry Winks and Harry Kane remain out.
The two sides last met a matter of days ago, playing out an exhilarating seven-goal thriller at the Etihad Stadium.
Goals from Raheem Sterling, Bernardo Silva and Sergio Aguero claimed victory on the night but ultimately, it would be Spurs who progressed to the Champions League semi-finals on away goals, having triumphed 1-0 in the first leg.
We picked up an important 1-0 win away to Tottenham in the Premier League back in October, with Riyad Mahrez’s early finish from Sterling’s cross proving to be the winner at Wembley.
“I hope we will give our best. We have five games – the Premier League and the FA Cup – and another game against Spurs. We will see.
“I think it will be another intense game. If you believe that Wednesday’s result doesn’t hurt or that we can just forget it, I will say: no.
“That is not the truth – we are human beings. We have to live with it and we have to compete with feeling."
"We didn't sleep too much (on Wednesday night) but the happiness allows you to feel strong and with energy, and of course now we're thinking about the game on Saturday.
"We don't have time to enjoy and we need to forget the Champions League now and try to be ready for Saturday because it's going to be a battle.
"It is our responsibility all together to try to make sure we are going to be there on Saturday with the capacity to fight and challenge them again."
Referee: Michael Oliver
Assistants: Stuart Burt, Simon Bennett
Fourth official: Chris Kavanagh
Manchester City manager addresses the media ahead of Saturday lunch-time's Premier League clash with Tottenham
The latest from Pep ahead of Saturday's big game...