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The game takes place at the Etihad Stadium, kick-off 5.30pm (GMT).
In the UK, the game is live on BT Sport 1, while fans around the world can find out how they can tune in via our global TV listings.
Davinson Sanchez (suspended), Toby Alderweireld (hamstring) and Victor Wanyama (knee) are out.
Craig Pawson is the man in the middle - he last officiated a City game in the 2-1 win at Huddersfield.
City took a two-goal lead last season but were pegged back with the match ending 2-2.
All the latest ahead of City's game with Spurs...
See if you agree with them...
Bernardo Silva says playing alongside David Silva is an education...