The young Blues trail the Reds by seven points in the Barclays U21 Premier League, but can close the gap to four points with a win over second-placed United at Leigh Sports Village.
Brandon Barker made two goals and scored the other in the win at Anfield and the young winger is hoping City claim the bragging rights to get themselves back on the trail of leaders Sunderland.
And with another league game against the Reds to come later this month, these fixtures could shape the remainder of Simon Davies' side's campaign.
"It’s a massive fixture, you dream about playing in these games," said Barker.
"There’s nothing better than playing in a City versus Manchester United fixture. It’s live on TV as well so there will be a lot of people watching. It’s going to be a good encounter.
"I’m a City fan so that will add that extra bit to if we win. It’s always good to play in these sort of games; they’re massive matches and as a player, it’s what you want to be involved in.
"It’s another game in the league, we want to attack every game in the exact same way but playing against United means that everyone gives that bit extra and everyone is at the peak of their game in training in the build up.
"I’m really looking forward to the game and hopefully, we can bring back three points."