The youngsters host the Cottagers at the Academy Stadium on Thursday 6 February, with kick-off at 7pm and tickets for the game are available to buy online.
On paper, it’s a mouth-watering clash, as U18 Premier League North Division leaders, City, battle it out with the team topping the Southern Division table.
Gareth Taylor's side, bolstered by the likes of Tommy Doyle and Taylor Harwood-Bellis, beat Aston Villa in the fourth round, whilst Fulham overcame Sheffield United by the same scoreline and both teams go into this tie knowing they will host Burnley in the quarter-final if they win.
Those fans who can’t make the game, can watch all the action live on CITY+.
Launched last month, our brand new content subscription is available across all digital platforms - mancity.com, Man City app and Smart TV.
The CITY+ subscription is designed to provide Cityzens with unrivalled access to new and exclusive City content.
It will allow you to watch full match replays of all men’s and women’s matches 24 hours after the final whistle, original CityTV productions, selected live women’s and academy games and much more.
Fans can sign up to a 30-day free trial, after which CITY+ is just £1.99GBP / month. For more information, visit mancity.com/City+