The Scotland international planted an exquisite chip over Mary Earps one year and a day after doing so in the 2020/21 meeting, to snatch a vital three points in Sunday's thrilling encounter.
Gareth Taylor's side produced a thoroughly dominant display, creating a hatful of chances, including a Jess Park strike that hit the post.
Just as the game looked to be heading for a stalemate, Weir - introduced from the bench - stepped forward and crafted yet another moment of magic against United to claim the win and the all important bragging rights!
Contested in front of a sell-out crowd at the Academy Stadium, the latest edition of the Manchester Derby was one of the most memorable yet.
Watch the video above to see the stunning goal in all its glory...