An impressive 17 members of Gareth Taylor's squad are in action over the break.
For our European contingent, that means taking part in the first UEFA Women's Nations League, which acts as part of the qualification process for the 2025 European Championships.
Elsewhere, City boast representatives in Olympic qualifying and various friendlies around the world.
As always, a City-focused match report on each fixture will be available to view on mancity.com and the official Man City app.
Find out all the important information around our involvement in the latest international break below...
UEFA Nations League
Of our 16 representatives at the upcoming international break, 11 will be involved in the first-ever Women's Nations League.
The competition serves as a potential route into the 2025 European Championships, with nations divided among three leagues based on their co-efficient ranking.
The winners of each of the top division 'League A' groups go on to compete in the finals later this year, being held in 2024.
Others will battle for promotion and relegation in the three leagues depending on their final group standings, which are then translated into the qualifying stages for the Euros.
Scotland (H) | Friday 22 September | 19:45
Netherlands (A) | Tuesday 26 September | 19:00
Belgium (A) | Friday 22 September | 19:30
England (H) | Tuesday 26 September | 19:00
City player: Julie Blakstad
Austria (H) | Friday 22 September | 18:00
Portugal (A) | Tuesday 26 September | 18:15
City player: Filippa Angeldahl
Spain (H) | Friday 22 September | 17:30
Italy (A) | Tuesday 26 September | 16:45
City player: Laia Aleixandri
Sweden (A) | Friday 22 September | 17:30
Switzerland (H) | Tuesday 26 September | 20:00
Khadija 'Bunny' Shaw has been selected as part of the Jamaica squad looking to qualify for next summer's Olympic games, held in Paris.
It's a straight shootout between Canada and the Reggae Girlz for the final CONCACAF spot, with the two reaching the two-legged play-off by virtue of finishing second and third in qualification.
City player: Khadija 'Bunny' Shaw
Canada (H) | Saturday 23 September | 01:00
Canada (A) | Wednesday 27 September | 00:00
U23 European League
They join eight other nations in the competition, with fixtures taking place over the course of the campaign.
Norway (A) | Thursday 21 September | 17:30
Belgium (H) | Monday 25 September | 19:00
City player: Yui Hasegawa
Argentina (H) | Saturday 23 September | 04:00
City player: Deyna Castellanos
Uruguay (H) | Friday 22 September | 00:00
Uruguay (H) | Tuesday 26 September | 00:00