City's quest to regain the trophy will begin on the last weekend of January with a trip to the Midlands, as FA Women's Super League clubs enter the tournament at the fourth round stage.
This will be the first meeting between the two sides in professional competition.
City have won the tournament on three occasions - most recently in the 2019/20 competition with an extra-time victory over Everton at Wembley Stadium, having also lifted the trophy in 2017 and 2019.
FA Women's National League North side Forest reached this stage with a 2-1 win at Stoke City, after defeating Lichfield City and then Wolverhampton Wanderers 4-0.
The fourth round ties are set to take place on Sunday 30 January 2022.
Fixture details and ticket information will be announced on mancity.com and our official app in the coming weeks.
Southampton v Bristol City
Newcastle United v Ipswich Town
Plymouth Argyle v Gillingham or Charlton Athletic
Liverpool v Lincoln City
Brighton & Hove Albion v Reading
Nottingham Forest v Manchester City
Aston Villa v Chelsea
Billericay Town v Coventry United
Durham v Blackburn Rovers
West Bromwich Albion v Southampton Women’s or Exeter City
Sheffield United v West Ham United
Birmingham City v Sunderland
Bridgwater United v Manchester United
Huddersfield Town v Everton
Tottenham Hotspur v Leicester City
Arsenal v London City Lionesses