Gareth Taylor’s side will travel to the Valhalla IP Stadium for the first leg on the 9 or 10 December before hosting the Swedish outfit for the reverse fixture on 15 or 16 December.
City reached the semi-finals of the competition in both 2017 and 2018, before being eliminated by eventual Champions Lyon on both occasions
In the past two seasons however, we suffered a frustrating exit in the early rounds at the hands of Atletico Madrid.
Damallsvenskan Champions Göteborg reached the quarter-finals of the tournament in 2012 and 2013 - edged out by Arsenal in the earlier campaign.
They returned to the competition in the 2019/20 season but were eliminated on away goals by eventual quarter-finalists Bayern Munich.
Interestingly, like City, they have two American players in their ranks in Emily Sonnett and Bri Folds.
Fixture information will be confirmed in due course...
St. Pölten (AUT) vs Zürich (SUI)
Lanchkhuti (GEO) vs Rosengård (SWE)
Göteborg (SWE) vs Manchester City (ENG)
Sparta Praha (CZE) vs Glasgow City (SCO)
Juventus (ITA) vs Lyon (FRA, holders)
ŽFK Spartak (SRB) vs Wolfsburg (GER)
Fiorentina (ITA) vs Slavia Praha (CZE)
Benfica (POR) vs Chelsea (ENG)
Pomurje (SVN) vs Fortuna Hjørring (DEN)
WFC-2 Kharkiv (UKR) vs BIIK-Kazygurt (KAZ)
Vålerenga (NOR) vs Brøndby (DEN)
Ajax (NED) vs Bayern München (GER)
PSV Eindhoven (NED) vs Barcelona (ESP)
FC Minsk (BLR) vs LSK Kvinner (NOR)
Górnik Łęczna (POL) vs Paris Saint-Germain (FRA)
Servette (SUI) vs Atlético Madrid (ESP)