The 23-year-old German international made the move to the Academy Stadium in the summer of 2017 and has scored 24 goals in 43 appearances in all competitions so far.
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The forward will depart City this summer however following the conclusion of her contract, with her set to return to her native Germany with VfL Wolfsburg.
Commenting on the news, Bremer said: “After three wonderful years in Manchester, I have taken the difficult decision to leave Manchester City and England at the end of this season and accept an offer from VfL Wolfsburg for a new challenge in my career.
“Manchester City is a fantastic club and I will never forget all the support I have received during my time here, from the coaches, staff, teammates and fans, especially during my rehabilitation from injury.
“It has been an amazing experience and I leave with so many fantastic memories - City will always be in my heart.
“I feel like I have grown as a person and as a player during my time in the Barclays FA Women’s Super League and I will always be thankful for the opportunities that I have had here.
“I believe however that the time is now right for the next chapter in my football journey and I am looking forward to the challenge of playing in the German Bundesliga.
“My only focus between now and May though will be ensuring that we finish the season as strongly as possible and I will be giving everything I have to make sure that the team succeeds.”
Gavin Makel, Head of Women’s Football, added: “This isn’t a decision that Pauline has taken lightly - we fully understand her reasons and she has been a credit to Manchester City during her time at the Club.
“She is a well-liked individual and the kind of player who gives 100% in everything that she does.
“We will wish her well in her next step, but we know that she will continue to give her absolute all in our remaining fixtures this season.”
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