Gareth Taylor's side lock horns with Spurs for a place in March's Conti Cup Final on Thursday 3 February, with kick-off scheduled for 19:00 (UK) at the Academy Stadium.
The game will be broadcast live on the FA Player, while tickets for all home games are on sale.
Three-time winners of the competition, City booked our place in the final four having finished top of Group B before defeating Bristol in the quarter-finals.
Spurs reached the semi-final stage by topping Group C with three wins from three and defeated Liverpool 1-0 in the last eight.
Meanwhile, our league fixture against Reading, which was due to take place in December, has also been rearranged.
The visit of the Royals will take place at the Academy Stadium on Wednesday 16 March at 19:00.
Ticket information will be released in due course. Stay tuned to mancity.com and our official app for all City news.
City v Tottenham Hotspur
Continental Cup semi-final
Thursday 3 February, 19:00
City v Reading
FA Women's Super League
Wednesday 16 March, 19:00