Gareth Taylor's side will welcome the Foxes to the Academy Stadium on Wednesday 29 September in a 19:00 (UK time) kick-off, seeking a place in the semi-finals.
City are the current holders of the trophy, having won the tournament in both 2020 and 2019. November's extra-time Wembley win over Everton marked Taylor's first piece of silverware at the helm - a matter of months into his new role.
Due to the global pandemic, the 2019/20 competition was forced to resume during the following season. As a result, the 2020/21 tournament was also delayed.
Impressive victories over Aston Villa and West Ham (8-0 and 5-1) earned our place in the last eight, while Leicester defeated Liverpool 1-0 and edged a five-goal thriller against Manchester United.
Women's FA Cup quarter-final
City v Leicester City Women
Wednesday 29 September
19:00 UK time