WHEN AND WHERE
The game kicks off at 8pm (UK) on Wednesday 26 February at the Bernabeu, Madrid.
In the UK, the game will be broadcast live on BT Sports and you can also keep up to date with all the action on ManCity.com's Matchday Centre or via our official Twitter platform: @ManCity.
Fans living outside of the UK should check out our global TV listings to find out how they can tune in wherever they are in the world.
Pep Guardiola has confirmed Raheem Sterling is fit and ready to play against the Spanish giants, but the game comes too soon for Leroy Sane.
Marco Asensio and Eden Hazard are both injured for Real Madrid.
LAST TIME OUT
City secured an impressive 1-0 win away to Leicester City on Saturday evening.
Gabriel Jesus scored the only goal of the game to extend City’s lead over third placed Leicester to seven points.
Real Madrid suffered a surprise 1-0 defeat to Levante – their first La Liga loss since September.
“You need to play good, first of all. You have to be strong and be quality and be many things. And you need luck, yes.
“In the knockout stage, the decisions at certain points are important. But we cannot control that. What we can control is to play as good as possible and then we will see. It is what it is."
Referee: Daniele Orsato (ITA)
Assistant referees: Lorenzo Manganelli (ITA), Alessandro Giallatini (ITA)
Video Assistant Referee: Massimiliano Irrati (ITA)
Assistant Video Assistant Referee: Ciro Carbone (ITA)
Fourth official: Daniele Doveri (ITA)
City last met Real Madrid in the Champions League semi-final second leg in May 2016.
Real Madrid won the game 1-0 and the tie 1-0 on aggregate.