Pep Guardiola's men are aiming to reach the last eight of Europe's elite competition for the sixth consecutive season, with RB Leipzig standing in our way.
The tie is finely poised ahead of just our second home fixture in seven, with the two sides having drawn 1-1 February's first leg.
Riyad Mahrez handed City the lead in Leipzig just before the half-hour mark, but the hosts replied through Josko Gvardiol with 20 to play.
Our official app allows you to follow all the action from what is sure to be an exciting encounter from one place.
Minute-by-minute text updates will begin in our Matchday Centre two hours before kick-off, while our Matchday Live show will begin at 18:40 (UK).
Shaun Goater, Paul Dickov and Steph Houghton are our special guests on the latest Matchday Live show, offering their expert insight at half-time and in greater detail after the final whistle.
They will also answer viewer questions throughout the broadcast, with audience participation actively encouraged on Matchday Live. To get in touch, send a WhatsApp to: +447537186538.
Ahead of Tuesday's showdown, check out the best images from our latest session via the gallery below...