Pep Guardiola's men host Watford on Saturday 23 April, with kick-off scheduled for 15:00 (UK).
City's victory over Brighton in midweek leaves us one point clear of Liverpool at the Premier League summit with six matches of the season remaining.
Our opponents, on the other hand, are currently 19th in the table and will be desperate to boost their survival bid and cause a major upset in the process.
With one eye also on Tuesday's Champions League semi-final first leg at home to Real Madrid, FPL managers have been left with some difficult selection dilemmas ahead of the weekend's action.
However, rest assured that the Scout is on hand as always to ease the burden with some expert insight in the latest of our regular FPL Scout Reports.
Kevin De Bruyne (£11.8m) has the home form to deliver another big return as Manchester City host Watford in Gameweek 34 of Fantasy Premier League.
The Belgian has averaged 9.2 points per start at the Etihad Stadium this season, scoring nine goals and supplying two assists.
Five of De Bruyne’s six double-figure hauls in 2021/22 have come in home matches.
The underlying numbers highlight his all-round influence on the City attack.
At home, De Bruyne’s totals of 16 shots on target and 29 chances created are both more than any team-mate.
Watford, meanwhile, arrive on the back of five defeats in six, conceding 15 goals in that run.
Opponent to watch
Emmanuel Dennis (£5.8m) is the visitors’ main threat, the Nigerian’s strike against Brentford last weekend taking his tally to 10 goals and six assists for the season.
Back in form: Dennis' goal in Watford's 2-1 defeat to Brentford was his first in seven Premier Leaue matches.
Other Premier League Pick
Mohamed Salah (£13.2m) and Mason Mount (£7.7m) are among the best armband picks for Gameweek 34.
Liverpool’s Salah hosts Everton on the back of a 19-point haul against Manchester United in midweek, his tenth double-figure return of the campaign.
Chelsea’s Mount, who has two matches against West Ham United and Man Utd, has four goals and three assists in his last four outings in all competitions.