Kick-off is scheduled for 20:00 (UK) as City look to get back to winning ways at the first time of asking.
Pep Guardiola's men were held to a 1-1 draw by a resilient Everton on New Year's Eve, but remain unbeaten in all competitions since returning from the World Cup.
But against a Chelsea side looking to reignite their Premier League campaign with a statement victory, three points is far from guaranteed.
It all points towards a thrilling encounter which leaves FPL managers with plenty of tough decisions before Monday's 16:00 (UK) deadline.
Check out the latest Scout Report below...
Joao Cancelo (£7.3m) can continue his fine record against Chelsea in Gameweek 19 of Fantasy Premier League.
The Portuguese delivered double-figure hauls in each of his two meetings with the Blues in the previous campaign.
Cancelo combined two assists with two clean sheets and five bonus points, totalling 23 points across those encounters.
Having been rested for Manchester City’s last two league outings, the full-back could return to the starting XI for Thursday’s clash at Stamford Bridge.
The underlying statistics further highlight Cancelo’s attacking potential this season.
He has produced 10 shots in away matches, more than any other defender.
One to watch
Raheem Sterling (£9.7m) has been the hosts’ form player, producing a goal and an assist over their previous two fixtures.
Indeed, only fellow England international Mason Mount (£7.6m) has earned more points in FPL this season than the former City winger.
Elsewhere, a Double Gameweek 19 for both Fulham and Chelsea lift the appeal of Willian (£5.5m) and Kai Havertz (£7.8m) as low-owned assets.
The Cottagers’ Willian visits Leicester City before entertaining Chelsea.
Havertz, meanwhile, faces Man City and Fulham on the back of two goals and an assist in his last four starts.