The first leg at the Estadio Jose Alvalade will be played on Tuesday, February 15.
And the return game at the Etihad is scheduled for Wednesday, March 9.
Both matches will kick-off at 8pm UK time.
Ticket and hospitality details will be released in due course.
Be the first to find out ticket information by registering your interest here: https://www.mancity.com/ticketing-and-hospitality/ucl-round-of-16
As usual we will have full coverage of both games right here on ManCity.com - including our live Matchday Centre and Matchday Live show.
And CITY+ subscribers can enjoy a full 90-minute replay of both matches from midnight on the day of the fixture.
Enjoy your first month of CITY+ free of charge. After that, CITY+ costs £1.99 a month.
Find out more and sign up, HERE.