As part of our regular series, the Scout provides expert analysis into a City star expected to pick up the points, as well as an opponent to watch and another Premier League player who could stand out across the weekend.
City Square Presenter Natalie Pike also reveals who she's selected for her FPL squad this week ahead of Southampton's visit to the Etihad Stadium on Saturday 18 September.
Leeds' trip to Newcastle this evening means the Gameweek Five transfer window slams shut at 18:30pm (UK), so take a look at our picks below if you're thinking about making a last minute change to your team!
Will Gabriel Jesus continue his fine form from the flank? Can Jack Grealish, fresh from his Champions League exploits, make it two goals in the space of three days? Or could free-kick specialist James Ward-Prowse pose a threat to Ederson and co.?
Check out who the Scout and Natalie have chose in our Gameweek Five predictions below...
The Scout: Gabriel Jesus (£8.6m) is seeking a third successive double-figure home haul as City entertain Southampton on Saturday afternoon.
The Brazilian has returned 11 and 12 points in his two outings at the Etihad Stadium this term, combining one goal with three assists over those matches against Norwich City and Arsenal.
Jesus played just nine minutes of Man City’s clash with RB Leipzig in the UEFA Champions League on Wednesday evening.
Yet the in-form forward still found time to score the hosts’ final goal in a 6-3 victory.
Pep Guardiola’s side have now scored 16 goals in their last three at the Etihad Stadium, highlighting their potential as major captaincy candidates in Fantasy.
City Square's Natalie Pike: I'm going for Jack Grealish (£8.0).
He was the first name on my team at the start of the year. I'm convinced he's going to have an incredible season and so far he's proving us all right!
After his debut in the Champions League, where he was fantastic and got the goal and assist, he's only going to get better and better.
Opponent to watch
FPL Scout: Set-piece specialist James Ward-Prowse (£6.5m) could be the main danger for the visitors.
The midfielder has scored at the Etihad in each of the last two seasons. His seven chances created is a team-leading total this term.
City Square's Natalie Pike: The Saints player I'm going to be watching closely is Adam Armstrong (£6.0).
He came from Blackburn during the summer off the back of an incredible season in the Championship scoring for fun.
He's got one goal so far, so he's already off the mark and with his talent he's going to get a run of form going at some point.
Premier League Pick
FPL Scout: Mohamed Salah (£12.5m) and Cristiano Ronaldo (£12.6m) are among the standout captaincy picks for Gameweek 5.
At home to Crystal Palace, Salah is the top-scoring midfielder in Fantasy thanks to three goals and two assists in the opening four Gameweeks.
Ronaldo, meanwhile, visits West Ham United on the back of three goals in two appearances in all competitions since returning to Manchester United.
City Square's Natalie Pike: The one to watch for me is Raphinha (£6.5).
Leeds haven't had a great start but we know it'll change, and Newcastle at home is a perfect time for them to kickstart their Premier League campaign.
Raphinha is an incredible talent and got his first international call-up a few weeks back as well, I'm expecting him to start making a big impact.
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