It's a battle between the top two in our first home fixture of 2022, as we welcome Chelsea to the Etihad Stadium in Saturday's 12:30 (UK) kick-off.
City could move 13 points clear at the Premier League summit with a positive result against Thomas Tuchel's men, which would also extend our winning sequence to 12 league matches.
However, Chelsea will offer a stern test of our credentials having avoided defeat in each of their last 11 games in all competitions.
It leaves FPL managers with some difficult selection decisions ahead of Friday's 18:00 deadline.
Thankfully, as part of our weekly series, the Scout is on hand to provide one City player, one opponent and another Premier League star they expect to stand out this weekend.
Check out the latest FPL Scout Report below...
Joao Cancelo’s (£7.0m) all-round potential can reward managers once again as Manchester City face Chelsea in Gameweek 22 of Fantasy Premier League.
The full-back produced 12 points in a 1-0 win at Stamford Bridge in Gameweek Six, supplying an assist and earning three bonus points.
Cancelo welcomes the London outfit on the back of 30 points in the last four Gameweeks, thanks to a goal, an assist and two clean sheets.
The Portuguese’s attacking threat could be a major weapon for Pep Guardiola’s side in Saturday’s lunchtime encounter.
His total of 19 shots at the Etihad Stadium ranks third for City this season.
Opponent to watch
Mason Mount (£7.7m) is Chelsea’s form player, combining four goals with three assists in his last eight matches.
Record haul: Mount's 24 points against Norwich in Gameweek Nine is the most earned by any Premier League player in a single match so far this season.
The midfielder grabbed a hat-trick, one assist and three bonus points in Chelsea's 7-0 win at Stamford Bridge in October.
Other Premier League pick
Elsewhere, Cristiano Ronaldo (£12.5m) and Harry Kane (£12.2m) are among the top armband options, with both set to play twice in Gameweek 22.
Ronaldo visits Aston Villa and Brentford on the back of four goals, an assist and 39 points in his last six outings for Manchester United.
Kane has scored in three of the last four Gameweek ahead of Tottenham Hotspur’s clashes with Arsenal and Leicester City.