Pep Guardiola's men welcome West Ham United to the Etihad Stadium on Sunday 28 November, with kick-off scheduled for 14:00 (UK).
City come into the tie off the back of a memorable 2-1 Champions League victory over Paris Saint-Germain, and will be keen to round off November with five successive wins in all competitions.
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Nonetheless, the Hammers will offer a stern test this weekend, as they aim to shake off a slender 1-0 loss away to Wolves in their last Premier League outing.
That defeat at Molineux aside, David Moyes' men have been one of the English top flight's form teams so far this season, and ended our four-year Carabao Cup reign with a penalty triumph back in October.
It promises to be an exciting encounter, and leaves FPL managers with plenty to ponder ahead of Saturday's 11:00 deadline.
As always the Scout eases those selection dilemmas in our regular series, pinpointing a City star, an opponent and one other Premier League player expected to pick up the points this weekend.
Check out the latest FPL Scout Report below...
Bernardo Silva (£7.2m) welcomes West Ham United in his most consistent form of 2021/22 Fantasy Premier League.
Manchester City’s midfielder has scored in back-to-back matches against Manchester United and Everton, earning eight points on each occasion.
Indeed, Bernardo has blanked only once in the last five Gameweeks, earning 33 points in Fantasy.
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The underlying numbers clearly highlight his all-round influence on Pep Guardiola’s attack from Gameweek 8 onwards.
The Portuguese’s totals of eight shots in the box and eight chances created both placed among the top two players for Man City.
Opponent to watch
Jarrod Bowen (£6.4m) has been West Ham’s form player recently, scoring twice and supplying six assists in the last eight Gameweeks.
Attacking threat: The threat indicator in FPL calculates players who are most likely to score across each Premier League match. Only West Ham teammate Michail Antonio and Liverpool duo Mohamed Salah and Sadio Mane boast a better threat indicator than Bowen in the entire Premier League.
The winger's six assists so far this season have also already matched his tally from his previous best campaign.
Premier League pick
Elsewhere, Mohamed Salah (£13.0m) and Harry Kane (£12.2m) are among the best captain contenders for Gameweek 13.
Both have strong records against their weekend opponents.
Salah has 46 points in four home meetings with Southampton, while Kane has produced 30 points in his last three visits to Burnley.
Impressive record: Harry Kane has grabbed nine goals and three assists in just 13 matches against Burnley across his career.
Manchester City v West Ham
The best place to follow every City game is on the official Man City app. You will not miss a beat.
Alistair Mann will provide commentary throughout the 90 minutes.
Minute-by-minute text updates are available in our Matchday Centre, starting at 12:00 (UK).
For those with push notifications turned on, you'll get alerted as soon as the teams are announced and goals go in.
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And our Matchday Live show with special guests will begin at just before 13:00 (UK).
Our special guests will then reconvene for a quick half-time debrief before a more in-depth post-match verdict, including their reaction to the full-time thoughts of Pep Guardiola and, time permitting, a player.
The guests will also answer viewer questions throughout the broadcast, with audience participation actively encouraged on Matchday Live. To get in touch, send a WhatsApp to: +447537186538.
Highlights from the match can be found later in the evening, while a full-match replay will also be available from midnight following the game with a CITY+ subscription.