Kick-off is scheduled for 17:30 (UK) on Saturday 3 September, as Pep Guardiola's men aim to continue our unbeaten start to the campaign.
And with Arsenal's match away to Manchester United not taking place until the following day, victory would see us move to the Premier League summit for 24 hours at least.
However, the hosts will be desperate to spark their season into life with a statement win, as they look to end a three match losing run this weekend.
The two sides served up a closely-fought encounter in last season's meeting, and it's likely to be no different this time around.
It leaves FPL managers with plenty of difficult decisions to make ahead of Saturday's 11:00 (UK) deadline.
Thankfully, the Scout is on hand to provide the latest stats and advice to ease those selection dilemmas.
Check out the Gameweek Six FPL Scout Report below...
Kevin De Bruyne (£12.2m) is among the best captain options in Gameweek 6 of Fantasy Premier League.
De Bruyne has averaged 6.8 points per start this season, producing a goal, three assists and three bonus points in those four outings.
The underlying numbers further back up his all-round influence on Pep Guardiola’s side.
The playmaker’s 15 chances created are more than any teammate, while his 13 shots and five shots on target both rank second.
Opponent to watch
Ollie Watkins (£7.4m) is the hosts’ form attacker for the weekend encounter, scoring once and supplying two assists in his last four appearances.
Raheem Sterling (£10.0m) and Darwin Nunez (£8.9m) could thrive as big differentials in Gameweek 6, with both players owned by under 10% of squads.
Chelsea’s Sterling welcomes West Ham United on the back of three goals and 23 points in his previous two appearances.
Nunez is expected to lead the line for Liverpool against Everton after serving a three-match suspension.