City, second in the Premier League and reigning champions, welcome league leaders Arsenal to the Etihad Stadium for a 20:00 (UK) kick-off on Friday.
It's sure to be an exhilarating battle with the winner to progress to the last 16 of the FA Cup.
Also fascinating on the night will be the interactions between Pep Guardiola and opposing manager Mikel Arteta, who was his assistant at the Etihad Stadium between 2016 and 2019.
Ahead of the fixture, the Blues have had a full week of training following last Sunday's 3-0 Premier League defeat of Wolves.
That culminated in a group session at the CFA today, which saw Guardiola run through his plans with his players and our squad put through their paces.
Take a look at the best photos from Thursday's session below...