City will face LSK Kvinner in the Women's Champions League Round of 16.
Nick Cushing's side will travel to Norway on 8/9 November before welcoming their opponents to the Academy Stadium on 15/16 November.
A first league title in the 2016 season, which was accompanied by a Continental Tyres Cup and a Champions League debut, clinched the Blues’ second qualification to the competition.
The Blues reached the semi-finals in their maiden campaign, defeating Zvezda Perm, Brondby IF and Fortuna Hjorring before falling to eventual competition winners Lyon. To reach this stage of this year's competition, they triumphed 6-0 on aggregate against SKN St Polten.
This is LSK's fourth appearance in the Champions League. The Norwegians have reached the Round of 16 once before in their best performance in the competition.
They defeated Brondby IF 3-1 on aggregate in the last round.
The quarter and semi-final draws will be conducted on Friday 24 November, before the competition then breaks to line up with the men's game, resuming in March for the quarter-finals (21 or 22 and 28 or 29).
The semi-finals will be played on 21 and 22 April (first leg) and 28 and 29 April 2018 (second leg).
The final will be held at the Valeriy Lobanovskyi Dynamo Stadium in Kiev, Ukraine on Thursday 24 May 2018.
Ticket information will be revealed in due course.