Having secured impressive victories in their last three games, the Blues will be full of confidence ahead of the clash and could find themselves top of the FA Women's Super League table by close of play.
City registered their first points on the board in the division with a triumph away at Arsenal Ladies on Sunday and have the chance to leapfrog five teams to the summit of the table - if only temporarily. Should Birmingham win at Arsenal however, they would pip MCWFC to top spot by a single point.
After four successive defeats earlier in the campaign, it was against Everton that Nick Cushing's side kick-started their season, snatching a last-gasp 1-0 victory at the Etihad Stadium in the Continental Cup.
Cushing however has warned against complacency ahead of this clash, stating: "We played them a few weeks ago and we were really happy to come away with a win. Still, just because we beat them then doesn’t mean we’ll automatically win this one!
"It only means we know what to expect from them – they’re a good team and they’re established in the FA Women’s Super League. We’ll have done our preparation on Monday and Tuesday and we’ll go into the game ready."
Kick-off is at 19:30 BST on Wednesday 21 May at the Manchester Regional Arena, Rowsley Street, M11 3FF.
Tickets are priced at £6 for adults and £4 for under-16s and can be purchased online or at the Etihad Stadium box office. Concessionary discounts are also available with tickets for 16-21 year-olds, over 65s and disabled supporters priced at £5.