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The John Smith’s Stadium is the venue for this tie, which kicks off at 3pm GMT.
The game will not be broadcast live in the UK, but you will be able to watch the highlights on Match of the Day, which is on BBC One at 10.30pm on Saturday evening.
Elias Kachunga is Town’s top scorer with 10, though defender Michael Hefele leads the FA Cup charts with two goals to his name.
Huddersfield sit third in the Championship and have lost only one of their last 10 league games.
The question is - how much of City's history in Yorkshire are you aware of?
Take our topical test and earn a celebratory GIF if you're good enough!
The press are looking forward to Manchester City's trip to Huddersfield in the FA Cup.
Former Manchester City star Andy Morrison interview