When and where:
The game is set to take place away at the London Stadium on Saturday 24 November, kick-off at 3pm GMT.
The match is not being shown live in the UK. Fans based outside the UK can find out where they can watch the match with our global TV listings...
Alternatively, you can follow our live Matchday Centre or our Twitter @ManCity for updates throughout the game.
The game will come too early for Bernardo Silva, who picked up a knock while away on international duty with Portugal, while Nicolas Otamendi is fit and ready to make his return.
Benjamin Mendy could be out for up to three months after he was forced to withdraw from the France squad during the international break and underwent surgery on his knee.
Kevin De Bruyne is ruled out with ligament damage which he sustained in the Carabao Cup win over Fulham.
Goalkeeper Claudio Bravo is a long-term absentee, having sustained an Achilles tendon injury. The Chilean 'keeper underwent scans, which confirmed a rupture in the tendon of his left foot.
Manuel Pellegrini's men have seven men on the injury table, including Manuel Lanzini (ACL), Ryan Fredericks (ankle), Andriy Yarmolenko (Achilles), Carlos Sanchez (knee) and Winston Reid (knee).
Jack Wilshere and Andy Carroll may return from ankle knocks, while Robert Snodgrass may also feature, having concluded his one-match suspension.
The last time...
The two sides last met in April, with City running out 4-1 victors at the London Stadium
Leroy Sane, Gabriel Jesus and Fernandinho were on the scoresheet, while former Blue Pablo Zabaleta put through his own net.
Aaron Cresswell had halved the deficit in the first half for the Hammers.
Pep Guardiola preview
Manuel Pellegrini preview
"I think City are improving every year. I left a couple of years ago and Pep has continued to do the work, buying new players and trying to improve the team and the club.
"I knew what would happen there and I am not disappointed with how it ended. I signed for three years and completed my contract. We improved a lot in those three years, winning the Premier League, reaching the FA Cup final and winning two League Cups."
Referee: Andre Marriner
Assistants: Scott Ledger, Simon Long
Fourth official: Keith Stroud
• The teams have met on 107 occasions competitively.
• City have tallied 53 victories, with 17 draws and 37 defeats.
• The Blues are unbeaten in our last six fixtures against the Hammers, winning the last five on the trot.
• City have only conceded five goals after 12 Premier League games this season - our lowest ever tally at this stage of a season.
• The Blues have never lost a home match in all competitions in which David Silva has scored (played 34, won 33, drawn one).
• For the first time in English top-flight history there are three unbeaten teams after 12 matches.
Notable player links
Pablo Zabaleta, Joe Hart, Carlos Tevez, Frank Lampard, Wayne Bridge, Craig Bellamy, Richard Wright, David James, Trevor Sinclair, Stuart Pearce, Paulo Wanchope, Marc-Vivien Foe, Eyal Berkovic, Steve Lomas,