When and where
The Houston Texan's NRG Stadium is the venue for the Blues first pre-season friendly, with the game kicking off at 8.30pm (CDT) on Thursday 20 July.
That's 2.30am on Friday 21 July for supporters in the UK.
If you want to tune in on TV, find out how you watch the game wherever you are in the world with our global TV listings.
City: Claudio Bravo (calf) is sidelined, while it remains to be seen whether Ilkay Gundogan (knee) - who has trained - is ready to return to competitive action.
We'll have an update from Pep Guardiola following Wednesday's pre-match press conference.
United: Marcos Rojo, Luke Shaw and Ashley Young will all miss out for the Reds.
Juan Mata is a doubt due to an ankle knock, but Matteo Darmian has trained after going off injured in the Real Salt Lake game.
April's 0-0 draw at the Etihad marked the last fixture between the sides, which kick-started a six game unbeaten run until the end of the season for Guardiola's men.
In what was a fairly uneventful game, Marouane Fellaini saw red for the away side in the 84th minute.
Watch: Warming up for United
City upped the ante ahead of the game with a morning and evening session in the searing Houston heat.
Tour diary: Day 2
Our team in Space City bring you the latest news on and off the pitch, which includes the singing talents of Check it out.
Gallery: Tuesday's training
Preparations for the ICC opener continued with a fitness session on Tuesday evening.
Read: Tour talking points
New boys, youngsters and a tough pre-season schedule are all up for discussion. Take a look...
Gallery: Sunshine sessions
The Texan sun was beating down as City were put through their paces in the first of two Tuesday training sessions.
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Watch: Hello Houston
A gentle training session signalled the start of Guardiola's squad's time in Houston as they limbered up following the 10-hour flight from Manchester.