The draw will take place on Monday, January 27 and will be shown live on The One Show on BBC 1.
It will be held at 7.20pm before the Bournemouth vs Arsenal match.
With just sixteen teams left in the competition, the race to Wembley is hotting up.
This season's FA Cup fifth round will take place in midweek during the week commencing Monday 2 March.
From this stage on there will also be no replays as any ties that are level after 90 minutes progressing to extra time and, if necessary, penalties to determine a winner on the night.
Ball numbers in full:
1: Manchester United
3: Southampton or Tottenham Hotspur
4: Sheffield Wednesday
5: AFC Bournemouth or Arsenal
6: Northampton Town or Derby County
7: Leicester City
8: Sheffield United
9: Reading or Cardiff City
10: West Bromwich Albion
11: Norwich City
12: Coventry City or Birmingham City
14: Newcastle United or Oxford United
16: Shrewsbury Town or Liverpool