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And Benjamin Mendy is on the bench, his first appearance in a matchday squad since the 1-0 win away at Burton Albion a month ago.
XI: Ederson, Danilo, Kompany, Otamendi, Zinchenko, Gundogan, De Bruyne, Silva, Mahrez, Sane, Aguero
Subs: Muric, Walker, Sterling, Bernardo, Mendy, Sandler, Foden
It's the usual 4-3-3 for City this evening.
In front of Ederson is a back four of Danilo on the right, Oleksandr Zinchenko on the left, with Vincent Kompany, who captains the side, and Nicolas Otamendi in the centre.
Ilkay Gundogan is likely to operate in the defensive-midfield role usually occupied by Fernandinho, with David Silva and Kevin De Bruyne just ahead of him providing guile.
And there's plenty of quality up top, with Mahrez on the right wing and Sane on the left supporting the prolific Sergio Aguero.
"We won one competition and now we are in the Premier League again," Guardiola said moments ago. "Two important games in three days."
West Ham, of course, provide a real threat. They are perhaps the Premier League's 'Jekyll and Hyde' side: brilliant on their day, somewhat disappointing on other occasions.
In Felipe Anderson they have probably the best attacking player outside the Top Six sides, Samir Nasri is a player City fans know all about and Manuel Pellegrini, who spent three years at City, is a manager committed to attractive football.
It should be a great occasion.
Manchester City have won 10 of their 12 league games against West Ham at the Etihad Stadium (D1, L1).
The Hammers' only league win there came in September 2015, when current boss Manuel Pellegrini was in charge of the home side.
Under Pep Guardiola, City have won all six of their league and cup games against the Hammers, scoring 22 goals and conceding just three.
The reigning champions have won 13 of their 14 top-flight games at the Etihad Stadium this season.
City have scored two goals or more in each of their last 15 home league matches - the longest such run in the top flight since Tottenham did so in 16 consecutive games in 1965.
After scoring three goals against both Arsenal and Chelsea, Sergio Aguero can become the first player to score Premier League hat-tricks in three consecutive home appearances.
Aguero has ended on the winning side in each of the last 23 league games he has started at the Etihad Stadium, scoring 29 goals and assisting seven more.
Tour 2019, presented by Visit Abu Dhabi, will see the team visit Asia.
All you need to know ahead of Wednesday night's big game...
City v West Ham: TV listings