De Bruyne injured his hamstring in the recent 1-0 over Tottenham and missed the midweek win over Manchester United, a game that saw Fernandinho withdrawn after suffering a knee problem.
Leroy Sane, fresh from scoring in the Manchester Derby, returns to the starting XI.
XI: Ederson, Walker, Kompany, Laporte, Zinchenko, Gundogan, Silva, Bernardo, Sane, Sterling, Aguero
Subs: Muric, Danilo, Stones, Mahrez, Otamendi, Jesus, Foden
City will play a 4-3-3 formation. Dominating possession is key to our style, but with Burnley’s direct approach, City will need to be prepared for their aerial and physical threat. That, perhaps, is why Vincent Kompany has been selected.
Ederson starts in goal, with Kompany and Aymeric Laporte just in front of him. Kyle Walker and Oleksandr Zinchenko will play as full-backs but look to get forward and add width to City’s attacks, as well as stepping into midfield to add numbers there when we have the ball.
Ilkay Gundogan continues in the holding role. He’s had a superb 2019, emerging as a key player during our 11-game winning run in the Premier League.
David Silva and Bernardo Silva will operate just ahead of him, with Leroy Sane and Raheem Sterling supporting Sergio Aguero in attack.
Manchester City are unbeaten in their last seven league and cup games against Burnley, winning six of those matches.
City have only won one of their past three games at Turf Moor (D1, L1), and have failed to keep a clean sheet in any of their four Premier League matches there.
The champions have beaten Burnley 5-0 twice this season in all competitions - no team has ever scored five goals against the same opponent three times in a single season in English league history.
Seventeen of City's last 22 league and cup goals against Burnley have come in the second half of matches, including eight of 10 this season.
Burnley have beaten the reigning champions once in each of their previous four Premier League seasons, and have won 44% of their games against the title holders (W4, D1, L4).
The Clarets are hoping to win three consecutive home league fixtures for the first time since a five-match streak in December 2016 and January 2017.
Burnley's win against Tottenham in February is their only victory in 15 Premier League home games against sides from the established top six (D2, L12).
They have conceded 62 league goals in 2018-19, compared to 39 last term - only the bottom three have worse records this season prior to the latest round of matches.
Ashley Barnes has scored 11 Premier League goals for Burnley this season, one short of an outright record for the Clarets.
Pep Guardiola's side have won 11 straight league games, the longest streak in the Premier League this season.
They can become the first team to end a top-flight season with 14 consecutive victories, breaking Arsenal's record of 13 in 2001-02.
City have won all 12 of their league matches this season against sides in the bottom seven (prior to the weekend's matches), scoring a total of 41 goals and conceding just four.
Sergio Aguero has scored eight goals in his last seven appearances against Burnley in all competitions.
Aguero is one short of becoming the second player to score at least 20 Premier League goals in six different seasons, emulating Alan Shearer (who did so in seven campaigns).
Aguero could also become the second player, after Thierry Henry, to achieve this feat in five consecutive seasons.