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Sergio Aguero, Leroy Sane and Nicolas Otamendi all drop to the bench, while John Stones, Ilkay Gundogan and Gabriel Jesus all start.
Benjamin Mendy is still side-lined with injury.
How we line up:
Ederson, Walker, Laporte, Stones, Delph, Fernandinho, Gundogan, D Silva, Bernardo, Sterling, G Jesus
Subs: Muric, Kompany, Otamendi, Sane, Aguero, Foden, Mahrez
We can assume Raheem Sterling and Bernardo will flank Jesus up front, with Gundogan will slip in alongside Fernandinho and David Silva in the middle.
Fabian Delph once again slots in at left-back with Stones returning to the starting XI alongside the ever-present Laporte.
Stats and milestones:
Lyon have only ever won once in eight Champions League games in England, drawing for and losing three. The solitary win was against Liverpool at Anfield nine years ago.
Lyon’s recent form in the competition is patchy, having won just three of their last 13 matches, seven of which were defeats.
The Ligue 1 side have scored just two goals in their last five Champions League matches, but they have conceded only three times.
City’s Champions League talisman is Raheem Sterling, who has scored eight goals and claimed six assists in his last 15 starts in the competition for the Blues.
All the major talking points ahead of Wednesday's Champions League opener
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