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The champions will be looking to maintain a 100% home record this season, following wins over Huddersfield Town and the Magpies.
John Stones is replaced by Nicolas Otamendi, Fabian Delph replaces Benjamin Mendy, Leroy Sane is in for Riyad Mahrez and Bernardo Silva replaces Gabriel Jesus.
Ederson, Walker, Laporte, Otamendi, Delph, Fernandinho, Silva, Bernardo, Sterling. Aguero, Sane
Subs: Muric, Zinchenko, Foden, G Jesus, Mahrez, Stones, Gundogan
It looks like the Blues will go 4-3-3 against Fulham.
The Blues will be keen to test a defence that is yet to keep a shut-out this campaign and has conceded nine goals in four games.
Sane and Sterling are likely to provide the attacking width to support Sergio Aguero, while David Silva, Bernardo and Fernandinho in midfield.
Stats and possible milestones:
David Silva makes his 350th appearance for City this afternoon. He is also one goal shy of 50 Premier League strikes.
TV info for City's home game with Fulham...
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