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Southampton are not mathematically safe and know a heavy loss against the Blues and a big Swansea win could yet send the Saints down – however unlikely.
With that in mind, expect the hosts to put a defensive formation out and attempt to keep the champions out.
City, however, have records to break and will look to end the campaign by reaching 100 points and adding the biggest title-winning points margin and goal difference to the already-long list of milestones achieved this season.
Your final #mancity line-up of the season!— Manchester City (@ManCity) May 13, 2018
City XI | Bravo, Danilo, Stones, Laporte, Delph, Fernandinho (C), Gundogan, De Bruyne, Bernardo, Sane, Sterling
Subs | Ederson, Walker, Kompany, Jesus, Zinchenko, Foden, Diaz
Presented by @HaysWorldwide #saintsvcity pic.twitter.com/mR2ALmTkRy
City make four changes from the side that beat Brighton 3-1 in midweek.
In come Raheem Sterling, Kevin De Bruyne, John Stones and Fabian Delph with Oleksandr Zinchenko, Yaya Toure, Gabriel Jesus and Vincent Kompany replaced.
City starting XI:
Bravo, Danilo, Laporte, Stones, Delph, Gundogan, Fernandinho, De Bruyne, Bernardo, Sterling, Sane
Subs: Ederson, Walker, Kompany, Jesus, Zinchenko, Foden, Diaz
Assists crown up for grabs
Bar some bizarre twist elsewhere, Leroy Sane and Kevin De Bruyne go into this game level on 15 Premier League assists.
If either manages to outdo the other and set up one or more goals today, they will be crowned Premier League assist king of the season.
Quite an accolade and the Blues could end with all top four spots in the Premier League assists chart – something that’s never happened before – with Raheem Sterling and David Silva next on the list of play-makers.
All the talking points ahead of Sunday's final game of the season