The indications are all three will get the nod again this afternoon in Nizhny Novgorod where the match kicks at 3pm local time (1pm UK) in what are expected to be sweltering conditions.
With Belgium, including Kevin De Bruyne, beating Tunisia 5-2 in their second group game yesterday, another England win would set up a fascinating opening stage finale next week between Southgate’s men and the Red Devils with the prize at stake being confirmed as group winners.
Elsewhere in Russia today, the second stage of group games wraps up with a double-header in Group H.
First up at 4pm in Yekaterinburg, Japan lock horns with Senegal at 4pm with both sides having won their opening games.
Then at 7pm in Kazan, Colombia and Poland will bid to get their World Cup campaigns up and running after defeats first time out.
Meanwhile, Saturday’s headlines were dominated by holders Germany who secured a dramatic last-gasp 2-1 win over Sweden to maintain their hopes of defending the crown they won in Brazil four years ago.
A first-half goal from Ola Toivonen had left Joachim Low’s side facing the prospect of being eliminated from the tournament.
But the Germans, who brought on City’s Ilkay Gundogan as a first-half substitute, levelled through Marco Reus and then overcame the handicap of seeing ex-City defender Jerome Boateng sent-off to secure a stunning win in the 95th minute through Toni Kroos’s brilliant free-kick.
Earlier in Group F, Mexico maintained their superb start to the World Cup with a 2-1 win over South Korea. Javier Hernandez netted his 50th international goal for his country after Carlo Vela’s penalty had given Mexico a first-half lead.
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Tottenham striker Son Heung-min’s stunning late strike then proved a mere consolation for South Korea.
Saturday’s other game saw Belgium overpower Tunisia 5-2 with Eden Hazard and Romelu Lukaku both bagging a brace of goals and City’s Kevin De Bruyne produce another assured midfield display.
Mexico 2-1 South Korea
Germany 2-1 Sweden
Belgium 5-2 Tunisia
England v Panama (1pm BBC)
Senegal v Japan (4pm BBC)
Colombia v Poland (7pm ITV)