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The Germany international was substituted off at half-time following a challenge from Bluebirds player Joe Bennett.
Sane has since undergone scans that confirm the 22-year-old is set for a spell on the sidelines - although no timeline has yet been set for his return.
Sane has scored 11 goals and produced 14 assists in all competitions this season - everyone at City wishes him a speedy recovery, and we'll keep you updated on his recovery here on mancity.com.
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