Pep Guardiola has made two changes to the side that beat Huddersfield Town on Sunday.
Oleksandr Zinchenko keeps his place in the 18, with Brahim Diaz joining him on the bench, while John Stones and Benjamin Mendy remain unavailable with hamstring and knee injuries, respectively. Phil Foden is not fully fit and doesn't make the squad.
City are currently on an 18-match winning run, which is a Club record, and another three points tonight would see us re-establish an eight-point lead over second-placed Manchester United in the Premier League table.
Starting XI: Ederson; Walker, Kompany, Otamendi, Delph; Fernandinho, Gundogan, De Bruyne; Sterling, Jesus, Agueo.
Subs: Bravo, Danilo, Mangala, Bernado, Silva, Zinchenko, Diaz
Guardiola has paired Aguero and Jesus together upfront, although don't be surprised to see the Brazilian drifting out to the left in the absence of Sane.
Fernandinho will hold, a role he has fulfilled brilliantly this term, with Gundogan and Kevin De Bruyne given licence to create.
As ever, Guardiola’s side will be fluid. One thing seems very likely, though: expect goals. And if Aguero is on the scoresheet, it will be his 100th at the Etihad.
Starting XI: Forster, Cédric, Yoshida, van Dijk, Hoedt, Bertrand, Højbjerg, Romeu, Lemina, Redmond, Long.
Subs: McCarthy, McQueen, Boufal, Tadić, Austin, Davis, Gabbiadini.