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Goals from Jordi Alba and Alvaro Morata put the hosts 2-0 up, before Silva’s quick-fire double made the game safe.
And Andres Iniesta added a fifth as Julen Lopetegui’s side ramped up their preparations for Russia 2018.
Silva is fourth on Spain’s list of all-time leading goalscorers with 35, and is now just three short of third-placed Fernando Torres and nine away from legendary Real Madrid striker Raul.
Spain take on Russia next in St. Petersburg on Tuesday.
Keep an eye on mancity.com throughout the week for updates on our international stars.
A detailed look at the numbers behind Leroy Sane's brilliant start to the season
Both John Stones and Gabriel Jesus impressed for England and Brazil respectively.
City's internationals in action...