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Youngsters Phil Foden, Brahim Diaz, Tosin Adarabioyo and Daniel Grimshaw all travel.
John Stones and Benjamin Mendy are ruled out with injury.
The travelling squad to face Shakhtar:
City take on Shakhtar in the Champions League on Wednesday 6 December for a 7.45pm (GMT) kick off.
Midfielder credits squad belief for several late victories against defensively minded teams.
Trio up for monthly gong.