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Ilkay Gundogan, Leroy Sane and Kyle Walker return with Bernardo, David Silva and Danilo making way for as the Blues look to stretch the lead at the top of the table to 14 points – at least for 24 hours.
Sane will resume his role on the left flank with Gundogan likely to be given a more advanced role for this game.
Sergio Aguero retains his place up front.
City’s changes are like for like so expect a fluid 4-3-3 formation with Fernandinho anchoring the midfield and Gundogan and Kevin De Bruyne free to roam.
Spurs are likely to use full-backs Danny Rose and Kieran Trippier to raid down the flanks and keep Walker and Fabian Delph busy.
One of today’s key battles could be Eliaquim Mangala against Harry Kane while at the other end Sergio Aguero against Eric Dier.
Spurs opt for a more physical presence in the middle with Moussa Dembele recalled along with Dele Alli.
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Stats and milestones
Aguero has scored 99 goals for City at the Etihad
Spurs haven't won away from home in the Premier league since beating Huddersfield 4-0 last September.
City are chasing a 16th successive Premier League win
The Blues haven't beaten Spurs in the last four meetings, losing three and drawing the other
News from the back pages...