City will take on West Ham in the FA Cup 3rd round on Friday 6 January.
It will be the Blues' first visit to the London Stadium - one of two night games City will face in the space of four weeks against the Hammers with, a Premier League trip scheduled for Wednesday, 1 February.
The Friday night fixture is a rare day of the week for the Blues to play with Pep Guardiola experiencing the competition for the first time.
The game will be screened live on BBC One and ticket details will be announced shortly.
Here's what happened when the teams last met.