Dzeko celebrated four years with City in January and was on target against Newcastle recently, breaking a four-month wait for a goal and he added his 50th in the 2-1 defeat to Liverpool.
To celebrate his half-century of league goals, here's a gallery of some of his most memorable moments so far...
The first Premier League goal - away to Blackburn in April 2011, Edin scores a 75th-minute winner as Champions League football edges ever closer.
Edin breaks Swansea's resistance to score on 57 minutes as the Blues power towards a 4-0 thrashing of the Welshmen in 2011.
Thumbs up for red-hot Dzeko as he bags his fourth of an unforgettable performance at White Hart Lane where City run riot, winning 5-1.
Edin strikes against Wolves in 2011 to break the deadlock at the Etihad and put City on their way to a 3-1 win that maintains a five-point gap at the top of the table.
Another crucial Dzeko goal as title-chasing City edge a nervy 1-0 win away to Wigan thanks to the Bosnian's 22nd-minute goal.
After scoring a vital injury-time equaliser against QPR on the final day, Dzeko was a huge part of City's 2011/12 title triumph and here he deservedly celebrates the Blues monumental comeback and glory.
Dzeko to the rescue! 10-man City, a goal down with ten minutes to play and looking likely to lose - until Edin climbed off the bench to score within a minute and then bag a last-gasp winner to secure a 2-1 win at The Hawthorns.
Dzeko scores City's second as the Blues end a 38-year wait for an away league win at Arsenal.
Dzeko bags a 66th-minute winner against a stubborn Crystal Palace at the Etihad - his 50th for the Club in all competitions...
Edin grabs one of the quickest derby goals of all times after just 43 seconds as City thrash United 3-0 at Old Trafford.
Another vital goal from Edin as his fourth minute strike at Selhurst Park settles the nerves and helps City to within three points of leaders Liverpool.
Relief all round as Dzeko breaks the deadlock against Aston Villa on 64 minutes as the Blues move to the brink of the 2013/14 title...
Deja vu for Edin as he celebrates another title - his goals in the second half of the campaign proved crucial to City overhauling Liverpool.
He's back - Edin breaks ends four months of frustration against Newcastle to cap a superb display.
And finally... Premier League goal number 50 as Edin levels the scores against Liverpool. There will be - no doubt - many more to come...
Look out for Edin giving his opinion on five of his best Premier League strikes for City in our exclusive video tomorrow.