Having already beaten cross-town rivals United this season in the Premier League, City will go into the game with confidence despite a tough run of results.
Ilkay Gundogan previews City's EFL clash with Manchester United
The potential for rotation for the EFL Cup fourth round tie sparked debate about possible team line-ups, while there was plenty of pick-up on boss Pep Guardiola's backing for star striker Sergio Aguero.
That was exactly what happened this weekend when Fernandinho replied to a fan in Brazil and invited him to be his mascot during the game against Southampton.
The Brazilian agreed to join City from Palmeiras in the summer – but he won’t join up with his new team-mates until the Brazilian league season is finishes in December.
Manchester City stars of the present and the future got together today for a team photo with a difference!